STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C16A11.3SPK domain-containing protein. (299 aa)    
Predicted Functional Partners:
sumv-2
Protein sumv-2; Influences the activity of genes involved in vulval development.
    
 
 0.568
mcrs-1
FHA domain-containing protein.
   
 
 0.564
B0353.1
Uncharacterized protein B0353.1.
    
 
 0.562
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
   
 
 0.541
utx-1
UTX (Ubiquitously transcribed TPR on X) homolog.
   
 
 0.522
cwp-5
Coexpressed With Polycystins.
   
 
 0.521
sin-3
Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC).
   
 
 0.492
lin-59
Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.
   
 
 0.472
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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