STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C16C10.4Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. (166 aa)    
Predicted Functional Partners:
acin-1
ACINus (Mammalian Apoptotic Chromatin condensation Inducer in the Nucleus) homolog.
   
 0.998
rnp-5
RRM domain-containing protein.
   
 0.996
pnn-1
Pinin_SDK_memA domain-containing protein.
   
 0.984
aly-3
FoP_duplication domain-containing protein.
   
 
 0.951
C02B10.4
RRM domain-containing protein.
   
 
 0.943
aly-2
FoP_duplication domain-containing protein.
   
 
 0.940
aly-1
FoP_duplication domain-containing protein.
   
 
 0.928
rnp-4
RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
   
 0.863
mag-1
Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family.
   
 0.861
cyn-13
Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.
   
  
 0.831
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.