Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA.

Protein her-1; Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a.

T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate.

Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family.

Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...]

Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also requ [...]

RRM domain-containing protein.

Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture. Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression. Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development. X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC). Requ [...]

Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...]