STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hil-4Histone H1.4; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (253 aa)    
Predicted Functional Partners:
hil-5
Histone H1.5; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
  
  
0.650
hmg-20
HMG box domain-containing protein.
   
 
 0.644
M195.2
Uncharacterized protein.
      
 0.583
C30G12.6
Uncharacterized protein C30G12.6.
   
  
 0.578
his-74
Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
   
 
 0.565
T08D2.7
Uncharacterized protein; Belongs to the protein kinase superfamily.
   
 
 0.561
rpa-2
RPA_C domain-containing protein.
   
 
 0.557
htz-1
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...]
   
 
 0.556
sex-1
Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily.
   
  
 0.555
hcp-2
HoloCentric chromosome binding Protein.
   
  
 0.544
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.