STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
frm-4FERM domain-containing protein. (672 aa)    
Predicted Functional Partners:
frm-10
FERM domain-containing protein.
      
 0.853
frm-9
FERM domain (Protein4.1-ezrin-radixin-moesin) family.
      
 0.853
frm-8
FERM domain (Protein4.1-ezrin-radixin-moesin) family.
      
 0.851
kin-32
Inactive tyrosine-protein kinase kin-32; Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells; Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
    
 
 0.703
max-1
Motor AXon guidance.
      
 0.667
nrx-1
NeuReXin related.
      
 0.516
kri-1
KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog.
    
 
 0.485
frm-1
FERM domain-containing protein.
   
  
0.433
nlg-1
Neuroligin-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission. Belongs to the type-B carboxylesterase/lipase family.
      
 0.414
lin-2
Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.
   
 
 0.412
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.