STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wdfy-3WD40 and FYVE domain protein. (3358 aa)    
Predicted Functional Partners:
atg-5
Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]
    
 
 0.863
wdfy-2
WD repeat and FYVE domain-containing protein 2; Plays a role in coelomocyte endocytosis.
   
  
 0.859
tbc-16
Rab-GAP TBC domain-containing protein.
      
 0.821
Y39G8C.2
Protein kinase domain-containing protein.
   
  
 0.811
dcap-1
mRNA_decap_C domain-containing protein.
    
 
 0.708
nep-4
Peptidase_M13 domain-containing protein.
      
 0.695
apm-3
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
      
 0.678
tbc-12
Rab-GAP TBC domain-containing protein.
   
  
 0.677
fkb-2
Peptidylprolyl isomerase.
      
 0.676
fkb-8
Peptidylprolyl isomerase.
      
 0.676
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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