node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
afmd-1 | bas-1 | D2024.2.1 | C05D2.4b.1 | Abhydrolase_3 domain-containing protein. | Biogenic Amine Synthesis related. | 0.905 |
afmd-1 | basl-1 | D2024.2.1 | C05D2.3.1 | Abhydrolase_3 domain-containing protein. | BAS-Like. | 0.905 |
afmd-1 | haao-1 | D2024.2.1 | K06A4.5.1 | Abhydrolase_3 domain-containing protein. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.865 |
afmd-1 | kmo-1 | D2024.2.1 | R07B7.5.1 | Abhydrolase_3 domain-containing protein. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.992 |
afmd-1 | kmo-2 | D2024.2.1 | R07B7.4b.1 | Abhydrolase_3 domain-containing protein. | FAD_binding_3 domain-containing protein. | 0.907 |
afmd-1 | kynu-1 | D2024.2.1 | C15H9.7.1 | Abhydrolase_3 domain-containing protein. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.988 |
afmd-1 | nkat-1 | D2024.2.1 | F28H6.3.1 | Abhydrolase_3 domain-containing protein. | Aminotran_1_2 domain-containing protein. | 0.923 |
afmd-1 | tdo-2 | D2024.2.1 | C28H8.11a.2 | Abhydrolase_3 domain-containing protein. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.989 |
bas-1 | afmd-1 | C05D2.4b.1 | D2024.2.1 | Biogenic Amine Synthesis related. | Abhydrolase_3 domain-containing protein. | 0.905 |
bas-1 | basl-1 | C05D2.4b.1 | C05D2.3.1 | Biogenic Amine Synthesis related. | BAS-Like. | 0.904 |
bas-1 | tatn-1 | C05D2.4b.1 | F42D1.2.1 | Biogenic Amine Synthesis related. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.919 |
bas-1 | tdo-2 | C05D2.4b.1 | C28H8.11a.2 | Biogenic Amine Synthesis related. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.910 |
bas-1 | tph-1 | C05D2.4b.1 | ZK1290.2a.1 | Biogenic Amine Synthesis related. | BH4_AAA_HYDROXYL_2 domain-containing protein. | 0.993 |
basl-1 | afmd-1 | C05D2.3.1 | D2024.2.1 | BAS-Like. | Abhydrolase_3 domain-containing protein. | 0.905 |
basl-1 | bas-1 | C05D2.3.1 | C05D2.4b.1 | BAS-Like. | Biogenic Amine Synthesis related. | 0.904 |
basl-1 | tatn-1 | C05D2.3.1 | F42D1.2.1 | BAS-Like. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.914 |
basl-1 | tdo-2 | C05D2.3.1 | C28H8.11a.2 | BAS-Like. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.903 |
basl-1 | tph-1 | C05D2.3.1 | ZK1290.2a.1 | BAS-Like. | BH4_AAA_HYDROXYL_2 domain-containing protein. | 0.973 |
haao-1 | afmd-1 | K06A4.5.1 | D2024.2.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | Abhydrolase_3 domain-containing protein. | 0.865 |
haao-1 | kmo-1 | K06A4.5.1 | R07B7.5.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.971 |