node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F14H12.3 | imb-1 | F14H12.3.1 | F28B3.8.1 | Uncharacterized protein. | Importin N-terminal domain-containing protein. | 0.913 |
F14H12.3 | npp-9 | F14H12.3.1 | F59A2.1b.3 | Uncharacterized protein. | Nuclear Pore complex Protein. | 0.785 |
F14H12.3 | ran-2 | F14H12.3.1 | C29E4.3a.1 | Uncharacterized protein. | Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. | 0.925 |
F14H12.3 | ran-3 | F14H12.3.1 | C26D10.1.1 | Uncharacterized protein. | Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. | 0.525 |
F14H12.3 | xpo-1 | F14H12.3.1 | ZK742.1a.1 | Uncharacterized protein. | Importin N-terminal domain-containing protein. | 0.918 |
imb-1 | F14H12.3 | F28B3.8.1 | F14H12.3.1 | Importin N-terminal domain-containing protein. | Uncharacterized protein. | 0.913 |
imb-1 | npp-15 | F28B3.8.1 | C29E4.4.1 | Importin N-terminal domain-containing protein. | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | 0.653 |
imb-1 | npp-9 | F28B3.8.1 | F59A2.1b.3 | Importin N-terminal domain-containing protein. | Nuclear Pore complex Protein. | 0.935 |
imb-1 | ran-1 | F28B3.8.1 | K01G5.4.1 | Importin N-terminal domain-containing protein. | GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. | 0.996 |
imb-1 | ran-2 | F28B3.8.1 | C29E4.3a.1 | Importin N-terminal domain-containing protein. | Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. | 0.915 |
imb-1 | ran-3 | F28B3.8.1 | C26D10.1.1 | Importin N-terminal domain-containing protein. | Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. | 0.816 |
imb-1 | ulp-1 | F28B3.8.1 | T10F2.3.1 | Importin N-terminal domain-containing protein. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.851 |
imb-1 | xpo-1 | F28B3.8.1 | ZK742.1a.1 | Importin N-terminal domain-containing protein. | Importin N-terminal domain-containing protein. | 0.847 |
npp-15 | imb-1 | C29E4.4.1 | F28B3.8.1 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Importin N-terminal domain-containing protein. | 0.653 |
npp-15 | npp-9 | C29E4.4.1 | F59A2.1b.3 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Nuclear Pore complex Protein. | 0.806 |
npp-15 | ran-2 | C29E4.4.1 | C29E4.3a.1 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate. | 0.901 |
npp-15 | smo-1 | C29E4.4.1 | K12C11.2.1 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.659 |
npp-15 | ubc-9 | C29E4.4.1 | F29B9.6.2 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. | 0.518 |
npp-15 | ulp-1 | C29E4.4.1 | T10F2.3.1 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.847 |
npp-15 | xpo-1 | C29E4.4.1 | ZK742.1a.1 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. | Importin N-terminal domain-containing protein. | 0.439 |