STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
daf-37G-protein coupled receptor daf-37; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-38 to control dauer formation and behavior. Receptor for the ascaroside pheromone ascr#2. Required for the response to dauer inducing pheromones, specifically the ascaroside ascr#2. May serve neuronal specific roles in response to ascr#2 with expression in ASI neurons controlling dauer formation in larvae, and expression in ASK neurons playing a role in longevity and hermaphrodite repulsion. May function upstream of the daf-11, daf-7 and daf-2 signaling pathways. (482 aa)    
Predicted Functional Partners:
daf-38
G-protein coupled receptor daf-38; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.
  
 
 0.996
srbc-64
Serpentine Receptor, class BC (Class B-like).
      
 0.931
srbc-66
Serpentine Receptor, class BC (Class B-like).
      
 0.929
srg-36
Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family.
      
 0.913
srg-37
Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family.
      
 0.912
gpa-3
Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...]
   
 
 0.806
srx-43
Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family.
      
 0.801
gpa-2
Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. Belongs to the G-alpha family. G(q) subfamily.
   
 
 0.745
srx-44
7TM_GPCR_Srx domain-containing protein.
      
 0.691
gtr-1
GPCR Thermal Receptor.
   
  
 0.663
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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