STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sma-6Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (636 aa)    
Predicted Functional Partners:
dbl-1
TGF_BETA_2 domain-containing protein.
   
 0.999
daf-4
Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
  
0.996
drag-1
RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family.
    
 0.972
sma-10
Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size.
   
 
 0.949
sma-2
Dwarfin sma-2; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis.
   
 0.949
sma-3
Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family.
   
 0.941
tig-3
TGF_BETA_2 domain-containing protein.
   
 0.929
sma-9
SMAll.
   
 
 0.918
daf-14
MH2 domain-containing protein.
   
 0.898
tig-2
TGF_BETA_2 domain-containing protein.
   
 0.885
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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