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sphk-1 protein (Caenorhabditis elegans) - STRING interaction network
"sphk-1" - Sphingosine kinase 1 in Caenorhabditis elegans
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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sphk-1Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (473 aa)    
Predicted Functional Partners:
hyl-1
Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons (368 aa)
     
 
  0.987
hyl-2
Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2 (329 aa)
     
 
  0.987
lagr-1
Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides (360 aa)
     
 
  0.984
tag-38
Protein TAG-38 (tag-38) mRNA, complete cds (542 aa)
       
  0.982
W02F12.2
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (272 aa)
       
  0.976
spl-1
Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction (552 aa)
       
  0.969
Y37E11AM.3
Protein Y37E11AM.3 (Y37E11AM.3) mRNA, complete cds; Belongs to the short-chain dehydrogenases/reductases (SDR) family (347 aa)
     
 
  0.967
ttm-5
Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase (362 aa)
         
  0.950
F33D4.4
Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily (360 aa)
         
  0.950
F53C3.13
PhosphoLipid PhosPhatase homolog; Protein F53C3.13, isoform a (385 aa)
     
  0.946
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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