STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sumv-1Protein sumv-1; Nuclear factor that influences the activity of genes involved in vulval development. (1024 aa)    
Predicted Functional Partners:
sumv-2
Protein sumv-2; Influences the activity of genes involved in vulval development.
   
  
 0.943
dnc-5
DyNactin Complex component.
   
 
 0.921
arp-11
Actin-Related Proteins; Belongs to the actin family.
   
 
 0.920
dnc-6
Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
   
 
 0.918
dnc-2
Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family.
   
 
 0.910
emc-1
EMC1_C domain-containing protein.
   
 
 0.894
dnc-1
CAP-Gly domain-containing protein.
   
 
 0.880
arp-1
Actin-Related Proteins; Belongs to the actin family.
   
 
 0.876
cap-2
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
    
 
 0.871
mys-2
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
  
 0.853
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (28%) [HD]