node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C36E6.2 | atg-3 | C36E6.2.1 | Y55F3AM.4a.1 | N_BRCA1_IG domain-containing protein. | Autophagy-related protein 3. | 0.631 |
C36E6.2 | atg-5 | C36E6.2.1 | Y71G12B.12a.1 | N_BRCA1_IG domain-containing protein. | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | 0.618 |
C36E6.2 | atg-7 | C36E6.2.1 | M7.5.1 | N_BRCA1_IG domain-containing protein. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.667 |
C36E6.2 | atg-9 | C36E6.2.1 | T22H9.2a.1 | N_BRCA1_IG domain-containing protein. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.563 |
C36E6.2 | epg-7 | C36E6.2.1 | T08A9.1.1 | N_BRCA1_IG domain-containing protein. | ATG11 domain-containing protein. | 0.632 |
C36E6.2 | epg-9 | C36E6.2.1 | Y69A2AR.7a.1 | N_BRCA1_IG domain-containing protein. | Ectopic P Granules. | 0.561 |
C36E6.2 | lgg-1 | C36E6.2.1 | C32D5.9.1 | N_BRCA1_IG domain-containing protein. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.707 |
C36E6.2 | lgg-2 | C36E6.2.1 | ZK593.6a.1 | N_BRCA1_IG domain-containing protein. | Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...] | 0.709 |
C36E6.2 | prx-5 | C36E6.2.1 | C34C6.6a.1 | N_BRCA1_IG domain-containing protein. | TPR_REGION domain-containing protein. | 0.552 |
C36E6.2 | ubq-2 | C36E6.2.1 | ZK1010.1.1 | N_BRCA1_IG domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.637 |
atg-3 | C36E6.2 | Y55F3AM.4a.1 | C36E6.2.1 | Autophagy-related protein 3. | N_BRCA1_IG domain-containing protein. | 0.631 |
atg-3 | atg-5 | Y55F3AM.4a.1 | Y71G12B.12a.1 | Autophagy-related protein 3. | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | 0.999 |
atg-3 | atg-7 | Y55F3AM.4a.1 | M7.5.1 | Autophagy-related protein 3. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.999 |
atg-3 | atg-9 | Y55F3AM.4a.1 | T22H9.2a.1 | Autophagy-related protein 3. | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. | 0.978 |
atg-3 | epg-7 | Y55F3AM.4a.1 | T08A9.1.1 | Autophagy-related protein 3. | ATG11 domain-containing protein. | 0.837 |
atg-3 | epg-9 | Y55F3AM.4a.1 | Y69A2AR.7a.1 | Autophagy-related protein 3. | Ectopic P Granules. | 0.790 |
atg-3 | lgg-1 | Y55F3AM.4a.1 | C32D5.9.1 | Autophagy-related protein 3. | Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...] | 0.998 |
atg-3 | lgg-2 | Y55F3AM.4a.1 | ZK593.6a.1 | Autophagy-related protein 3. | Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to [...] | 0.982 |
atg-5 | C36E6.2 | Y71G12B.12a.1 | C36E6.2.1 | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | N_BRCA1_IG domain-containing protein. | 0.618 |
atg-5 | atg-3 | Y71G12B.12a.1 | Y55F3AM.4a.1 | Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] | Autophagy-related protein 3. | 0.999 |