STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hnd-1BHLH domain-containing protein. (226 aa)    
Predicted Functional Partners:
unc-120
MADS-box domain-containing protein.
   
  
 0.901
hlh-2
BHLH domain-containing protein.
   
 
 0.778
ehn-3
Zinc finger protein ehn-3; Together with the zinc finger protein ztf-16, plays a role in gonadogenesis, specifically in somatic gonad precursor cell development. This is possibly by regulating tra-1 gene expression. Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.772
tbx-8
T-box transcription factor tbx-8; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-9.
   
  
 0.765
scrt-1
SCRaTch (Zinc finger transcriptional repressor) homolog.
   
 
 0.737
tbx-9
T-box transcription factor tbx-9; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-8.
   
  
 0.712
nhr-2
Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
   
  
 0.709
hlh-19
BHLH domain-containing protein.
      
 0.697
pal-1
Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...]
   
  
 0.685
nhr-26
Nuclear Hormone Receptor family.
      
 0.663
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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