STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C44C10.9Uncharacterized protein. (234 aa)    
Predicted Functional Partners:
apl-1
Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...]
   
 
 0.863
mlt-11
Uncharacterized protein.
    
 
 0.768
tep-1
TEP (ThiolEster containing Protein).
   
 
 0.709
unc-89
Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...]
   
 
 0.535
crt-1
Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...]
    
 
 0.441
acn-1
Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...]
   
 
 0.428
tnc-2
Troponin C, isoform 2; Belongs to the troponin C family.
   
   0.412
ZC434.9
ShKT domain-containing protein.
   
 
 0.405
pah-1
Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
   
 
 0.403
F02D8.4
Peptidase_M14 domain-containing protein.
   
 
 0.401
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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