node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atf-5 | mak-2 | T04C10.4.1 | C44C8.6.2 | BZIP domain-containing protein. | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.900 |
ccch-1 | mak-1 | F38B7.1a.1 | K08F8.1a.2 | CCCH-type zinc finger putative transcription factor. | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.796 |
ccch-1 | mak-2 | F38B7.1a.1 | C44C8.6.2 | CCCH-type zinc finger putative transcription factor. | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.815 |
cebp-1 | ets-4 | D1005.3.2 | F22A3.1b.1 | C/EBP (CCAAT/enhancer-binding protein) homolog. | Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too [...] | 0.955 |
cebp-1 | mak-2 | D1005.3.2 | C44C8.6.2 | C/EBP (CCAAT/enhancer-binding protein) homolog. | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.979 |
cebp-1 | pmk-3 | D1005.3.2 | F42G8.4a.1 | C/EBP (CCAAT/enhancer-binding protein) homolog. | Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.823 |
ets-4 | cebp-1 | F22A3.1b.1 | D1005.3.2 | Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too [...] | C/EBP (CCAAT/enhancer-binding protein) homolog. | 0.955 |
ets-4 | mak-2 | F22A3.1b.1 | C44C8.6.2 | Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too [...] | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.900 |
hsf-1 | hsp-25 | Y53C10A.12.1 | C09B8.6a.1 | HSF_DOMAIN domain-containing protein. | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | 0.558 |
hsf-1 | mak-1 | Y53C10A.12.1 | K08F8.1a.2 | HSF_DOMAIN domain-containing protein. | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.769 |
hsf-1 | mak-2 | Y53C10A.12.1 | C44C8.6.2 | HSF_DOMAIN domain-containing protein. | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.797 |
hsf-1 | pmk-1 | Y53C10A.12.1 | B0218.3.1 | HSF_DOMAIN domain-containing protein. | Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] | 0.766 |
hsf-1 | pmk-2 | Y53C10A.12.1 | F42G8.3a.1 | HSF_DOMAIN domain-containing protein. | Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. | 0.425 |
hsf-1 | pmk-3 | Y53C10A.12.1 | F42G8.4a.1 | HSF_DOMAIN domain-containing protein. | Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.461 |
hsp-25 | hsf-1 | C09B8.6a.1 | Y53C10A.12.1 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | HSF_DOMAIN domain-containing protein. | 0.558 |
hsp-25 | mak-1 | C09B8.6a.1 | K08F8.1a.2 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.891 |
hsp-25 | mak-2 | C09B8.6a.1 | C44C8.6.2 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.886 |
mak-1 | ccch-1 | K08F8.1a.2 | F38B7.1a.1 | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | CCCH-type zinc finger putative transcription factor. | 0.796 |
mak-1 | hsf-1 | K08F8.1a.2 | Y53C10A.12.1 | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | HSF_DOMAIN domain-containing protein. | 0.769 |
mak-1 | hsp-25 | K08F8.1a.2 | C09B8.6a.1 | MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | 0.891 |