STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C46H3.2Uncharacterized protein. (920 aa)    
Predicted Functional Partners:
gpn-1
GlyPicaN; Belongs to the glypican family.
    
 
 0.676
vab-1
Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...]
   
 
 0.577
C25G6.3
Uncharacterized protein.
 
  
 
 0.547
lin-12
Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling.
  
   0.542
sli-1
Suppressor of LIneage defect.
   
 
 0.532
mlt-3
ANK_REP_REGION domain-containing protein.
  
 
   0.501
ikke-1
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1; Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy.
   
 
 0.498
Y39G8B.5
Protein kinase domain-containing protein.
   
 
 0.498
F26F4.12
ANK_REP_REGION domain-containing protein.
  
 
   0.493
glp-1
Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan.
  
   0.487
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.