STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gcy-8Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1. (1152 aa)    
Predicted Functional Partners:
pde-2
Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.
   
 0.917
ndx-4
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
     
 0.902
hap-1
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.900
pde-5
Probable 3',5'-cyclic phosphodiesterase pde-5; Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
   
 0.865
tax-2
Cyclic nucleotide-binding domain-containing protein.
   
 
 0.864
tax-4
Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...]
   
 
 0.864
pde-1
Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.
   
 
 0.853
ttx-1
Homeobox domain-containing protein.
   
  
 0.813
srtx-1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.812
cat-4
GTP cyclohydrolase 1; Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.
     
  0.800
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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