node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C35A5.8 | imb-3 | C35A5.8.1 | C53D5.6.1 | Uncharacterized protein. | Importin N-terminal domain-containing protein. | 0.872 |
C35A5.8 | ran-5 | C35A5.8.1 | R12C12.2.1 | Uncharacterized protein. | RanBD1 domain-containing protein. | 0.929 |
cdc-14 | imb-3 | C17G10.4h.1 | C53D5.6.1 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Importin N-terminal domain-containing protein. | 0.844 |
ima-1 | imb-1 | T19B10.7.2 | F28B3.8.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Importin N-terminal domain-containing protein. | 0.979 |
ima-1 | imb-3 | T19B10.7.2 | C53D5.6.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Importin N-terminal domain-containing protein. | 0.876 |
ima-1 | npp-11 | T19B10.7.2 | F53F10.5.2 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Nuclear Pore complex Protein. | 0.837 |
ima-1 | npp-3 | T19B10.7.2 | K12D12.2.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Nuclear Pore complex Protein. | 0.724 |
ima-1 | npp-4 | T19B10.7.2 | Y54E5A.4.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Nuclear Pore complex Protein. | 0.774 |
ima-1 | ran-1 | T19B10.7.2 | K01G5.4.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. | 0.715 |
ima-1 | ran-5 | T19B10.7.2 | R12C12.2.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | RanBD1 domain-containing protein. | 0.482 |
ima-1 | ulp-1 | T19B10.7.2 | T10F2.3.1 | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.616 |
imb-1 | ima-1 | F28B3.8.1 | T19B10.7.2 | Importin N-terminal domain-containing protein. | Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family. | 0.979 |
imb-1 | imb-3 | F28B3.8.1 | C53D5.6.1 | Importin N-terminal domain-containing protein. | Importin N-terminal domain-containing protein. | 0.967 |
imb-1 | npp-11 | F28B3.8.1 | F53F10.5.2 | Importin N-terminal domain-containing protein. | Nuclear Pore complex Protein. | 0.997 |
imb-1 | npp-3 | F28B3.8.1 | K12D12.2.1 | Importin N-terminal domain-containing protein. | Nuclear Pore complex Protein. | 0.835 |
imb-1 | npp-4 | F28B3.8.1 | Y54E5A.4.1 | Importin N-terminal domain-containing protein. | Nuclear Pore complex Protein. | 0.847 |
imb-1 | ran-1 | F28B3.8.1 | K01G5.4.1 | Importin N-terminal domain-containing protein. | GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. | 0.996 |
imb-1 | ulp-1 | F28B3.8.1 | T10F2.3.1 | Importin N-terminal domain-containing protein. | Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form. | 0.851 |
imb-3 | C35A5.8 | C53D5.6.1 | C35A5.8.1 | Importin N-terminal domain-containing protein. | Uncharacterized protein. | 0.872 |
imb-3 | cdc-14 | C53D5.6.1 | C17G10.4h.1 | Importin N-terminal domain-containing protein. | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | 0.844 |