STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cca-1Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1885 aa)    
Predicted Functional Partners:
egl-19
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
  
0.976
ccb-1
GuKc domain-containing protein.
   
 
 0.976
tag-180
VWFA domain-containing protein.
   
 
 0.858
unc-36
Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of [...]
   
 
 0.838
cav-2
Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family.
   
 
 0.836
unc-2
EF-hand domain-containing protein.
  
0.831
ccb-2
SH3 domain-containing protein.
     
 0.827
unc-68
Uncharacterized protein.
   
  
 0.779
unc-105
Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
  
 0.775
cav-1
Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
    
 
 0.764
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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