STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ifta-1WD_REPEATS_REGION domain-containing protein. (1246 aa)    
Predicted Functional Partners:
daf-10
Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa.
  
 0.998
dyf-2
WD repeat-containing protein dyf-2; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues.
  
 0.998
che-11
Uncharacterized protein.
  
 0.996
ift-139
Tetratricopeptide repeat protein 21 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility. Functions in cilia biogenesis. Belongs to the TTC21 family.
  
 0.992
dyf-1
Tetratricopeptide repeat protein 30 homolog; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors. Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motili [...]
  
 
 0.970
dyf-3
Clusterin-associated protein 1 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis ; Belongs to the CLUAP1 family.
  
 
 0.968
dyf-13
Intraflagellar transport protein 56 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.
  
 
 0.967
che-2
CHE-2 protein.
  
 0.964
osm-6
Osm-6 protein.
  
 
 0.952
dyf-11
Uncharacterized protein.
  
 
 0.948
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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