STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aipr-1Aryl hydrocarbon receptor Interacting Protein (AIP) Related. (342 aa)    
Predicted Functional Partners:
hsp-90
Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...]
    
 0.982
ahr-1
Aryl hydrocarbon receptor protein 1; Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance.
    
 0.980
daf-41
Co-chaperone protein daf-41; Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures. Belongs to the p23/wos2 family.
    
 0.937
mrps-18.C
Mitochondrial Ribosomal Protein, Small.
   
  
 0.807
F41G3.20
Uncharacterized protein.
      
 0.805
dnj-8
J domain-containing protein.
 
 
 
 0.798
hsp-75
HATPase_c domain-containing protein.
   
 
 0.782
ttc-4
TeTratriCopeptide repeat domain protein related.
   
 
 0.739
gras-1
PDZ domain-containing protein.
   
  
 0.731
rpap-3
RPAP3_C domain-containing protein.
   
  
 0.727
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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