STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
toe-2Target Of ERK kinase MPK-1. (621 aa)    
Predicted Functional Partners:
T08A11.1
DEP domain-containing protein.
   
  
 0.920
cnt-2
Arf-GAP with ANK repeat and PH domain-containing protein cnt-2; GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis; Belongs to the centaurin gamma-like family.
      
 0.759
pig-1
Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding.
   
  
 0.737
grp-1
GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules.
   
  
 0.688
ham-1
Stork_head domain-containing protein.
      
 0.669
ubc-12
NEDD8-conjugating enzyme ubc-12; Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins. Plays a role in male tail tip morphogenesis.
   
  
 0.539
ran-1
GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
   
 
 0.521
uba-2
SUMO-activating enzyme subunit uba-2; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).
   
  
 0.444
hcp-6
Condensin-2 complex subunit.
   
  
 0.424
zen-4
Kinesin-like protein.
   
  
 0.416
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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