node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
afmd-1 | bas-1 | D2024.2.1 | C05D2.4b.1 | Abhydrolase_3 domain-containing protein. | Biogenic Amine Synthesis related. | 0.905 |
afmd-1 | basl-1 | D2024.2.1 | C05D2.3.1 | Abhydrolase_3 domain-containing protein. | BAS-Like. | 0.905 |
afmd-1 | haao-1 | D2024.2.1 | K06A4.5.1 | Abhydrolase_3 domain-containing protein. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.865 |
afmd-1 | kmo-1 | D2024.2.1 | R07B7.5.1 | Abhydrolase_3 domain-containing protein. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.992 |
afmd-1 | kmo-2 | D2024.2.1 | R07B7.4b.1 | Abhydrolase_3 domain-containing protein. | FAD_binding_3 domain-containing protein. | 0.907 |
afmd-1 | kynu-1 | D2024.2.1 | C15H9.7.1 | Abhydrolase_3 domain-containing protein. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.988 |
afmd-1 | nkat-1 | D2024.2.1 | F28H6.3.1 | Abhydrolase_3 domain-containing protein. | Aminotran_1_2 domain-containing protein. | 0.923 |
afmd-1 | nkat-3 | D2024.2.1 | R03A10.4a.2 | Abhydrolase_3 domain-containing protein. | Aminotran_1_2 domain-containing protein. | 0.925 |
afmd-1 | pfd-6 | D2024.2.1 | F21C3.5.1 | Abhydrolase_3 domain-containing protein. | Probable prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for positioning of the mitotic spindle. | 0.877 |
afmd-1 | tdo-2 | D2024.2.1 | C28H8.11a.2 | Abhydrolase_3 domain-containing protein. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.989 |
bas-1 | afmd-1 | C05D2.4b.1 | D2024.2.1 | Biogenic Amine Synthesis related. | Abhydrolase_3 domain-containing protein. | 0.905 |
bas-1 | basl-1 | C05D2.4b.1 | C05D2.3.1 | Biogenic Amine Synthesis related. | BAS-Like. | 0.904 |
bas-1 | tdo-2 | C05D2.4b.1 | C28H8.11a.2 | Biogenic Amine Synthesis related. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.910 |
basl-1 | afmd-1 | C05D2.3.1 | D2024.2.1 | BAS-Like. | Abhydrolase_3 domain-containing protein. | 0.905 |
basl-1 | bas-1 | C05D2.3.1 | C05D2.4b.1 | BAS-Like. | Biogenic Amine Synthesis related. | 0.904 |
basl-1 | tdo-2 | C05D2.3.1 | C28H8.11a.2 | BAS-Like. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism. | 0.903 |
haao-1 | afmd-1 | K06A4.5.1 | D2024.2.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | Abhydrolase_3 domain-containing protein. | 0.865 |
haao-1 | kmo-1 | K06A4.5.1 | R07B7.5.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.971 |
haao-1 | kmo-2 | K06A4.5.1 | R07B7.4b.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | FAD_binding_3 domain-containing protein. | 0.862 |
haao-1 | kynu-1 | K06A4.5.1 | C15H9.7.1 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. | 0.996 |