STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
atx-2Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2 [...] (1026 aa)    
Predicted Functional Partners:
M142.5
AD domain-containing protein.
    
 
 0.994
cgh-1
ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
   
 
 0.981
pab-1
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.
   
 
 0.960
snr-2
Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family.
    
 
 0.940
pab-2
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.
   
 
 0.919
T07F10.3
Uncharacterized protein.
    
 
 0.905
Y48G1C.9
Sm domain-containing protein.
    
 
 0.855
K07H8.10
RRM domain-containing protein.
   
 
 0.836
gtbp-1
Ras-Gtpase-activating protein SH3 (Three) domain-Binding Protein.
   
 
 0.756
impt-1
Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family.
    
 
 0.747
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.