STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)    
Predicted Functional Partners:
skr-2
SKp1 Related (Ubiquitin ligase complex component).
   
 0.999
skr-1
Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination.
   
 0.999
cand-1
Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
   
 0.999
rbx-1
RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
   
 0.999
skr-3
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.998
skr-7
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.998
skr-9
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.997
skr-8
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.997
skr-10
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.997
skr-13
SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family.
   
 0.996
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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