STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E02H4.6Protein kinase domain-containing protein. (303 aa)    
Predicted Functional Partners:
T23D8.3
Protein LTV1 homolog; Belongs to the LTV1 family.
    
 
 0.723
lin-42
Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...]
    
 
 0.632
F14H3.6
Uncharacterized protein.
   
    0.592
byn-1
Uncharacterized protein byn-1; Belongs to the bystin family.
    
 
 0.571
riok-2
Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
    
 
 0.560
F14D7.2
Uncharacterized protein.
   
    0.543
Y39B6A.10
Uncharacterized protein.
   
   0.543
F02H6.2
Uncharacterized protein.
   
    0.515
F14H3.4
Uncharacterized protein.
   
    0.515
C17E7.4
Uncharacterized protein.
   
    0.512
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.