STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unc-79Uncoordinated protein 79. (2092 aa)    
Predicted Functional Partners:
unc-80
Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.
   
 
 0.999
nlf-1
NCA Localization Factor.
   
 
 0.999
nca-2
Four domain-type voltage-gated ion channel alpha-1 subunit.
   
 
 0.993
unc-2
EF-hand domain-containing protein.
   
 
 0.959
egl-19
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
   
 
 0.954
unc-77
Uncharacterized protein.
   
 
 0.952
ift-139
Tetratricopeptide repeat protein 21 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility. Functions in cilia biogenesis. Belongs to the TTC21 family.
   
 
 0.936
C27F2.1
WD Repeat protein.
   
 
 0.934
F17C8.6
Uncharacterized protein.
   
 
 0.934
W03G1.5
Uncharacterized protein.
   
 
 0.932
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.