STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tofu-6Embryonic developmental protein tofu-6; Required maternally for early embryonic cell divisions. May have a role in DNA replication. (367 aa)    
Predicted Functional Partners:
Y23H5A.3
Uncharacterized protein.
   
 
 0.998
C35D10.13
Twenty-One u (U) antagoniST.
   
 
 0.972
ife-3
Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]
   
 
 0.969
F35G12.11
Enhancer of rudimentary homolog; May have a role in the cell cycle.
   
 
 0.950
tofu-7
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.918
pid-1
21U-RNA biogenesis factor pid-1; Plays a role in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing.
   
 
 0.913
tofu-1
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.911
tofu-2
B30.2/SPRY domain-containing protein.
   
  
 0.879
tofu-5
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.846
erh-1
Enhancer of rudimentary homolog; May have a role in the cell cycle.
   
  
 0.844
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.