STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kcnl-2CaMBD domain-containing protein. (855 aa)    
Predicted Functional Partners:
shw-3
BTB domain-containing protein; Belongs to the potassium channel family.
   
  
 0.760
kcnl-1
CaMBD domain-containing protein.
  
 
0.710
twk-33
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.707
twk-35
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.703
srw-145
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.703
F59F3.6
BTB_2 domain-containing protein.
   
  
 0.688
shw-1
BTB domain-containing protein; Belongs to the potassium channel family.
   
  
 0.681
best-24
Bestrophin homolog 24; Forms chloride channels.
   
  
 0.676
clh-3
Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...]
   
  
 0.673
kcnl-3
Small conductance calcium-activated potassium channel-like protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium.
  
 
0.643
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.