STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ddr-2Discoidin domain-containing receptor tyrosine kinase B; Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9. (797 aa)    
Predicted Functional Partners:
col-99
Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
   
 
 0.709
nstp-1
Nucleotide Sugar TransPorter family.
      
 0.696
Y5H2B.1
Uncharacterized protein.
      
 0.693
emb-9
Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons.
   
 
 0.687
shc-1
SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...]
    
 
 0.666
nid-1
NIDogen (Basement membrane protein).
   
  
 0.625
agr-1
AGRin (Synaptic protein) homolog family member.
   
  
 0.539
svh-1
Serine protease svh-1; Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1. Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones. May play a role in gonad development.
      
 0.537
lam-3
LAMinin related. See also lmb.
   
  
 0.519
let-2
Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development.
   
 
 0.504
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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