STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F13C5.2Bromo domain-containing protein. (374 aa)    
Predicted Functional Partners:
bet-2
BET (Two bromodomains) family protein.
   
  
0.537
chd-3
Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.
   
 
 0.528
taf-7.1
TAFII55_N domain-containing protein.
   
 
 0.526
taf-7.2
TAFII55_N domain-containing protein.
    
 
 0.512
ekl-4
Uncharacterized protein.
    
 
 0.501
ssl-1
Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
   
 
 0.497
cec-8
Chromo domain-containing protein.
   
 
 0.470
epg-2
Ectopic P granules protein 2; Involved in autophagy. Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1. Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May also play a role in the removal of sepa-1 from somatic cells.
   
   0.463
htz-1
Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...]
   
 
 0.459
taf-1
Transcription initiation factor TFIID subunit 1; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Required for early embryonic development. Essential for embryonic transcription of several genes.
    
 
 0.456
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.