STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhx-4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (749 aa)    
Predicted Functional Partners:
ttc-37
TeTratriCopeptide repeat domain protein related.
      
 0.815
aqp-7
AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
 0.696
moma-1
MICOS complex subunit MIC27; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).
      
 0.673
spr-2
Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family.
      
 0.660
nrfl-1
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.
   
 
 0.552
pmr-1
Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
  
 
 0.540
alh-13
Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
     
 0.535
R07H5.9
Uncharacterized protein.
      
 0.530
nhx-5
Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  
  
0.490
C05E11.6
Uncharacterized protein; Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
      
 0.465
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.