STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
drl-1Protein drl-1; Negatively regulates lifespan and health span probably by participating in nutrient sensing. (589 aa)    
Predicted Functional Partners:
ccm-3
Programmed cell death protein 10 homolog; Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.
    
 
 0.861
K07A9.3
CCM (Cerebral Cavernous Malformation) gene homolog.
    
 
 0.831
klf-2
Kruppel-Like Factor (Zinc finger protein).
    
 
 0.823
cyp-32B1
CYtochrome P450 family; Belongs to the cytochrome P450 family.
   
 
 0.718
elo-4
Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family.
      
 0.697
Y45F10D.10
Integrin Cytoplasmic domain-Associated Protein homolog.
      
 0.681
ugt-50
Putative UDP-glucuronosyltransferase ugt-50.
      
 0.660
ugt-16
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
      
 0.660
cyp-35B1
CYtochrome P450 family; Belongs to the cytochrome P450 family.
   
 
 0.601
cyp-44A1
Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
   
 
 0.577
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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