STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgc-4Ligand-gated ion channel 4; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (635 aa)    
Predicted Functional Partners:
D2007.2
Uncharacterized protein D2007.2.
      
 0.911
pxd-1
PleXin Domain containing.
      
 0.908
drn-1
GTP-binding protein drn-1; Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.
   
  
 0.901
dmsr-2
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.896
npr-29
Probable G-protein coupled receptor npr-29; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.893
ncs-2
Neuronal calcium sensor 2; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner; Belongs to the recoverin family.
   
  
 0.701
ldb-1
LID domain-containing protein.
      
 0.699
nep-21
Neprilysin-21; Probable cell surface protease.
   
  
 0.549
lgc-55
Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
    0.528
lgc-5
Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
  
   
0.473
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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