STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srp-8SERPIN domain-containing protein; Belongs to the serpin family. (372 aa)    
Predicted Functional Partners:
bath-38
BTB and MATH domain-containing protein 38.
      
 0.970
dpy-2
Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.
    
 
 0.702
epg-5
Ectopic P granules protein 5; Involved in the maturation of autophagosomes into autolysosomes during starvation-induced autotrophy. Specifically, involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome.
      
 0.693
eng-1
Glyco_hydro_85 domain-containing protein.
      
 0.620
sec-22
Yeast SEC homolog; Belongs to the synaptobrevin family.
   
  0.536
ile-1
L-type lectin-like domain-containing protein.
    
 0.527
nsf-1
Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family.
   
  0.517
col-99
Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).
    
 0.516
emb-9
Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons.
    
 0.516
T19D12.4
VWFA domain-containing protein.
   
 
  0.516
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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