STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F21D12.3Aa_trans domain-containing protein. (496 aa)    
Predicted Functional Partners:
Y41E3.19
Uncharacterized protein.
      
 0.863
srr-10
Serpentine Receptor, class R.
   
 
 0.858
srj-45
Serpentine Receptor, class J.
      
 0.857
angl-1
Endo/exonuclease/phosphatase domain-containing protein.
      
 0.839
str-74
Seven TM Receptor.
      
 0.544
sin-3
Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC).
    
 
 0.467
sdha-1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
   
 
 0.403
ikke-1
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1; Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy.
   
 
 0.402
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.