STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F22B5.4Uncharacterized protein. (164 aa)    
Predicted Functional Partners:
nhr-57
Nuclear hormone receptor family member nhr-57; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
   
  
 0.819
C25H3.7
Uncharacterized protein.
      
 0.806
hrg-4
Heme transporter hrg-4; Heme transporter that mediates heme uptake across the plasma membrane; Belongs to the HRG family.
      
 0.803
mrp-5
Uncharacterized protein.
      
 0.759
Y37A1A.2
Uncharacterized protein.
      
 0.741
hpo-26
Uncharacterized protein.
      
 0.699
col-137
Col_cuticle_N domain-containing protein.
      
 0.698
vhl-1
Von Hippel-Lindau tumor suppressor homolog; Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility. Belongs to the VHL family.
      
 0.693
fecl-1
FErroChelatase-Like; Belongs to the ferrochelatase family.
      
 0.692
nspd-4
Nematode Specific Peptide family, group D.
      
 0.692
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.