STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F28C10.3Uncharacterized protein; Belongs to the protein kinase superfamily. (349 aa)    
Predicted Functional Partners:
rskn-1
Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
     
0.800
mpk-1
Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...]
   
0.799
let-363
Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...]
   
 
 0.784
crh-1
BZIP domain-containing protein.
   
 0.784
daf-15
Raptor_N domain-containing protein.
    
 
 0.664
atp-5
ATP synthase subunit.
   
 
 0.644
atp-3
ATP synthase subunit.
   
 
 0.599
sinh-1
Stress-activated map kinase-interacting protein 1 homolog; May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
   
 
 0.598
Y69A2AR.18
Uncharacterized protein.
   
 
 0.596
rps-6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan ; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 
 0.590
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.