STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ceh-22Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer. (379 aa)    
Predicted Functional Partners:
pha-4
Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...]
   
 
 0.862
psa-3
Meis_PKNOX_N domain-containing protein.
      
 0.820
end-1
GATA-type domain-containing protein.
    
 
 0.723
peb-1
FLYWCH-type domain-containing protein.
   
  
 0.719
hlh-6
Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity.
   
 
 0.712
myo-2
Myosin-2; Muscle contraction.
   
  
 0.705
tbx-2
T-box protein 2; Involved in the development of pharyngeal muscles derived from the ABa lineage.
   
 
 0.702
let-522
Uncharacterized protein.
   
  
 0.686
vab-3
Homeobox domain-containing protein.
   
 
0.668
unc-37
Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation.
    
 
 0.654
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.