STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
set-10MYND-type domain-containing protein. (430 aa)    
Predicted Functional Partners:
dot-1.2
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
   
 
 0.844
set-11
SET (Trithorax/polycomb) domain containing.
      
 0.780
set-12
Histone-lysine N-methyltransferase.
   
  
 0.755
sas-5
Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.
   
  
 0.581
his-40
Histone H3.
   
 0.516
set-2
Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...]
   
 
 0.465
C07A12.7
GAT domain-containing protein.
      
 0.420
set-18
MYND-type domain-containing protein.
  
   
0.416
set-32
SET domain-containing protein.
   
  
 0.408
sas-4
Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size.
   
  
 0.404
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.