STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
igcm-1ImmunoGlobulin-like Cell adhesion Molecule family. (1073 aa)    
Predicted Functional Partners:
syg-1
Synaptogenesis protein syg-1; Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F- actin assembly at the synaptic region and for axon branch formation.
  
0.892
sax-7
Fibronectin type-III domain-containing protein.
  
 
 
 0.803
syg-2
Synaptogenesis protein syg-2; Cell adhesion protein. Determines synapse formation. Required for correct localization of syg-1 at synaptic sites.
   
 
0.802
zig-1
Zwei Ig domain protein zig-1; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
   
 
 0.740
igcm-3
ImmunoGlobulin-like Cell adhesion Molecule family.
   
  
 0.737
sma-1
SMAll.
   
  
 0.714
byn-1
Uncharacterized protein byn-1; Belongs to the bystin family.
      
 0.698
Y105E8A.1
Glutaredoxin domain-containing protein.
      
 0.698
set-29
SET domain-containing protein.
      
 0.692
dnsn-1
Downstream Neighbor of SoN homolog.
      
 0.690
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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