node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fcho-1 | snb-1 | F56D12.6a.1 | T10H9.4.1 | FCH domain Only (FCH stands for Fes/CIP4 homology domain). | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.506 |
fcho-1 | snt-2 | F56D12.6a.1 | F42G9.7.1 | FCH domain Only (FCH stands for Fes/CIP4 homology domain). | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. | 0.718 |
fcho-1 | unc-41 | F56D12.6a.1 | C27H6.1a.1 | FCH domain Only (FCH stands for Fes/CIP4 homology domain). | Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. | 0.781 |
fcho-1 | unc-57 | F56D12.6a.1 | T04D1.3d.1 | FCH domain Only (FCH stands for Fes/CIP4 homology domain). | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. | 0.684 |
rab-3 | rimb-1 | C18A3.6a.1 | Y39A3CL.2.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | RIM Binding protein. | 0.945 |
rab-3 | snb-1 | C18A3.6a.1 | T10H9.4.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.942 |
rab-3 | snn-1 | C18A3.6a.1 | Y38C1BA.2b.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | ATP-grasp domain-containing protein. | 0.939 |
rab-3 | snt-2 | C18A3.6a.1 | F42G9.7.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. | 0.890 |
rab-3 | sph-1 | C18A3.6a.1 | F42G8.11.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | MARVEL domain-containing protein. | 0.749 |
rab-3 | unc-18 | C18A3.6a.1 | F27D9.1a.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. | 0.911 |
rab-3 | unc-41 | C18A3.6a.1 | C27H6.1a.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family. | 0.412 |
rab-3 | unc-57 | C18A3.6a.1 | T04D1.3d.1 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. | 0.815 |
rab-3 | unc-64 | C18A3.6a.1 | F56A8.7a.2 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] | 0.869 |
rimb-1 | rab-3 | Y39A3CL.2.1 | C18A3.6a.1 | RIM Binding protein. | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. | 0.945 |
rimb-1 | snb-1 | Y39A3CL.2.1 | T10H9.4.1 | RIM Binding protein. | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | 0.511 |
rimb-1 | snn-1 | Y39A3CL.2.1 | Y38C1BA.2b.1 | RIM Binding protein. | ATP-grasp domain-containing protein. | 0.759 |
rimb-1 | snt-2 | Y39A3CL.2.1 | F42G9.7.1 | RIM Binding protein. | Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. | 0.722 |
rimb-1 | unc-18 | Y39A3CL.2.1 | F27D9.1a.1 | RIM Binding protein. | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. | 0.626 |
rimb-1 | unc-64 | Y39A3CL.2.1 | F56A8.7a.2 | RIM Binding protein. | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] | 0.673 |
snb-1 | fcho-1 | T10H9.4.1 | F56D12.6a.1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. | FCH domain Only (FCH stands for Fes/CIP4 homology domain). | 0.506 |