F43C11.1 protein (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F43C11.1

Uncharacterized protein. (179 aa)

Predicted Functional Partners:

nas-17

0.546

E02H9.1

0.538

F13E9.10

0.538

F18E9.7

0.538

T26A8.3

0.513

F47C12.6

0.497

M7.9

0.468

F35C5.3

0.463

Y46D2A.3

0.459

C14F11.7

0.457

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C14F11.7	E02H9.1	C14F11.7.1	E02H9.1.1	Uncharacterized protein.	Uncharacterized protein.	0.465
C14F11.7	F13E9.10	C14F11.7.1	F13E9.10.1	Uncharacterized protein.	DUF148 domain-containing protein.	0.549
C14F11.7	F18E9.7	C14F11.7.1	F18E9.7a.1	Uncharacterized protein.	Uncharacterized protein.	0.536
C14F11.7	F43C11.1	C14F11.7.1	F43C11.1b.1	Uncharacterized protein.	Uncharacterized protein.	0.457
C14F11.7	M7.9	C14F11.7.1	M7.9.1	Uncharacterized protein.	DUF148 domain-containing protein.	0.584
C14F11.7	T26A8.3	C14F11.7.1	T26A8.3.1	Uncharacterized protein.	Uncharacterized protein.	0.615
C14F11.7	nas-17	C14F11.7.1	K03B8.2.1	Uncharacterized protein.	Zinc metalloproteinase nas-17; Metalloprotease.	0.592
E02H9.1	C14F11.7	E02H9.1.1	C14F11.7.1	Uncharacterized protein.	Uncharacterized protein.	0.465
E02H9.1	F13E9.10	E02H9.1.1	F13E9.10.1	Uncharacterized protein.	DUF148 domain-containing protein.	0.541
E02H9.1	F18E9.7	E02H9.1.1	F18E9.7a.1	Uncharacterized protein.	Uncharacterized protein.	0.497
E02H9.1	F43C11.1	E02H9.1.1	F43C11.1b.1	Uncharacterized protein.	Uncharacterized protein.	0.538
E02H9.1	T26A8.3	E02H9.1.1	T26A8.3.1	Uncharacterized protein.	Uncharacterized protein.	0.463
F13E9.10	C14F11.7	F13E9.10.1	C14F11.7.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.549
F13E9.10	E02H9.1	F13E9.10.1	E02H9.1.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.541
F13E9.10	F18E9.7	F13E9.10.1	F18E9.7a.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.545
F13E9.10	F35C5.3	F13E9.10.1	F35C5.3.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.525
F13E9.10	F43C11.1	F13E9.10.1	F43C11.1b.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.538
F13E9.10	F47C12.6	F13E9.10.1	F47C12.6.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.538
F13E9.10	M7.9	F13E9.10.1	M7.9.1	DUF148 domain-containing protein.	DUF148 domain-containing protein.	0.592
F13E9.10	T26A8.3	F13E9.10.1	T26A8.3.1	DUF148 domain-containing protein.	Uncharacterized protein.	0.592

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About