STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trf-1TNF Receptor Associated Factor (TRAF) homolog. (462 aa)    
Predicted Functional Partners:
ikb-1
ANK_REP_REGION domain-containing protein.
    
 
 0.912
tol-1
TIR domain-containing protein.
   
 
 0.908
pik-1
Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.
   
 
 0.904
rap-1
Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family.
   
 
 0.845
ubq-2
Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...]
    
   0.840
F31F7.2
VWFA domain-containing protein.
    
 
 0.826
trk-1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
 
 0.791
F25D7.5
EGF-like domain-containing protein.
    
 
 0.768
ptp-4
Tyrosine-protein phosphatase 4.
   
  
 0.739
T12E12.3
Uncharacterized protein.
      
 0.700
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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