node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C46F11.6 | atfs-1 | C46F11.6.1 | ZC376.7a.2 | Ubiquitin-like protein. | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | 0.850 |
C46F11.6 | clpp-1 | C46F11.6.1 | ZK970.2d.1 | Ubiquitin-like protein. | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | 0.830 |
C46F11.6 | dve-1 | C46F11.6.1 | ZK1193.5a.1 | Ubiquitin-like protein. | Homeobox domain-containing protein. | 0.940 |
C46F11.6 | haf-1 | C46F11.6.1 | C30H6.6.1 | Ubiquitin-like protein. | HAlF transporter (PGP related). | 0.761 |
C46F11.6 | ned-8 | C46F11.6.1 | F45H11.2.1 | Ubiquitin-like protein. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.890 |
C46F11.6 | ubl-5 | C46F11.6.1 | F46F11.4.1 | Ubiquitin-like protein. | Ubiquitin-like protein 5. | 0.907 |
F19F10.9 | mfap-1 | F19F10.9.1 | F43G9.10.1 | Uncharacterized protein. | Microfibrillar-associated protein 1; Involved in pre-mRNA splicing. | 0.995 |
F19F10.9 | prp-38 | F19F10.9.1 | D1054.14.1 | Uncharacterized protein. | Yeast PRP (Splicing factor) related. | 0.699 |
F19F10.9 | prp-8 | F19F10.9.1 | C50C3.6.1 | Uncharacterized protein. | Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. | 0.994 |
F19F10.9 | ubl-5 | F19F10.9.1 | F46F11.4.1 | Uncharacterized protein. | Ubiquitin-like protein 5. | 0.992 |
atfs-1 | C46F11.6 | ZC376.7a.2 | C46F11.6.1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | Ubiquitin-like protein. | 0.850 |
atfs-1 | clpp-1 | ZC376.7a.2 | ZK970.2d.1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | 0.915 |
atfs-1 | dve-1 | ZC376.7a.2 | ZK1193.5a.1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | Homeobox domain-containing protein. | 0.983 |
atfs-1 | haf-1 | ZC376.7a.2 | C30H6.6.1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | HAlF transporter (PGP related). | 0.882 |
atfs-1 | ubl-5 | ZC376.7a.2 | F46F11.4.1 | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | Ubiquitin-like protein 5. | 0.911 |
clpp-1 | C46F11.6 | ZK970.2d.1 | C46F11.6.1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | Ubiquitin-like protein. | 0.830 |
clpp-1 | atfs-1 | ZK970.2d.1 | ZC376.7a.2 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] | 0.915 |
clpp-1 | dve-1 | ZK970.2d.1 | ZK1193.5a.1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | Homeobox domain-containing protein. | 0.924 |
clpp-1 | haf-1 | ZK970.2d.1 | C30H6.6.1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | HAlF transporter (PGP related). | 0.823 |
clpp-1 | ubl-5 | ZK970.2d.1 | F46F11.4.1 | ATP-dependent Clp protease proteolytic subunit 1, mitochondrial; Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates; Belongs to the peptidase S14 family. | Ubiquitin-like protein 5. | 0.878 |