STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F49F1.5ShKT domain-containing protein. (159 aa)    
Predicted Functional Partners:
F01D5.3
Uncharacterized protein.
   
  
 0.814
F01D5.2
Uncharacterized protein.
   
  
 0.812
F01D5.5
Uncharacterized protein.
   
  
 0.752
sedl-1
Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response; Belongs to the TRAPP small subunits family. Sedlin subfamily.
      
 0.665
F10A3.1
Uncharacterized protein.
      
 0.660
T24B8.5
Uncharacterized protein.
   
  
 0.538
T02E1.7
Uncharacterized protein T02E1.7; Belongs to the SURF4 family.
    
 
 0.507
unc-89
Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...]
   
 
 0.501
nhr-63
Nuclear Hormone Receptor family.
    
 
 0.477
dkf-2
Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
      
 0.468
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.