STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pqe-1Putative RNA exonuclease pqe-1; Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins. It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration. Regulates gene expression in neurons. (1647 aa)    
Predicted Functional Partners:
C08B6.8
Probable oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
   
 0.943
C05C8.5
Exonuclease domain-containing protein.
   
 
0.905
Y56A3A.33
Exonuclease domain-containing protein.
   
 
 
0.900
pcn-1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.778
panl-3
PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]
   
 
 0.721
osm-10
Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
      
 0.699
crn-3
HRDC domain-containing protein.
  
 0.604
hipr-1
Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family.
   
  
 0.601
mog-3
Sex determining protein MOG-3.
   
  
 0.563
F02E9.10
WD_REPEATS_REGION domain-containing protein.
      
 0.539
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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