node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C38D4.4 | F58G11.3 | C38D4.4.1 | F58G11.3a.1 | Uncharacterized protein. | Uncharacterized protein. | 0.591 |
C38D4.4 | glh-1 | C38D4.4.1 | T21G5.3.1 | Uncharacterized protein. | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | 0.531 |
C38D4.4 | meg-3 | C38D4.4.1 | F52D2.4.1 | Uncharacterized protein. | Uncharacterized protein. | 0.801 |
C38D4.4 | pgl-1 | C38D4.4.1 | ZK381.4b.1 | Uncharacterized protein. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.607 |
C38D4.4 | pgl-3 | C38D4.4.1 | C18G1.4a.1 | Uncharacterized protein. | Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...] | 0.446 |
F58G11.3 | C38D4.4 | F58G11.3a.1 | C38D4.4.1 | Uncharacterized protein. | Uncharacterized protein. | 0.591 |
F58G11.3 | glh-1 | F58G11.3a.1 | T21G5.3.1 | Uncharacterized protein. | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | 0.462 |
F58G11.3 | meg-3 | F58G11.3a.1 | F52D2.4.1 | Uncharacterized protein. | Uncharacterized protein. | 0.869 |
F58G11.3 | pgl-1 | F58G11.3a.1 | ZK381.4b.1 | Uncharacterized protein. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.555 |
F58G11.3 | pgl-3 | F58G11.3a.1 | C18G1.4a.1 | Uncharacterized protein. | Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...] | 0.479 |
glh-1 | C38D4.4 | T21G5.3.1 | C38D4.4.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Uncharacterized protein. | 0.531 |
glh-1 | F58G11.3 | T21G5.3.1 | F58G11.3a.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Uncharacterized protein. | 0.462 |
glh-1 | meg-1 | T21G5.3.1 | K02B9.1.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Uncharacterized protein. | 0.532 |
glh-1 | meg-2 | T21G5.3.1 | K02B9.2.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Uncharacterized protein. | 0.539 |
glh-1 | meg-3 | T21G5.3.1 | F52D2.4.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Uncharacterized protein. | 0.856 |
glh-1 | mex-5 | T21G5.3.1 | W02A2.7.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA. | 0.728 |
glh-1 | pgl-1 | T21G5.3.1 | ZK381.4b.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...] | 0.989 |
glh-1 | pgl-3 | T21G5.3.1 | C18G1.4a.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...] | 0.967 |
glh-1 | pptr-1 | T21G5.3.1 | W08G11.4.1 | ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. | Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...] | 0.705 |
mbk-2 | meg-1 | F49E11.1b.1 | K02B9.1.1 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. | Uncharacterized protein. | 0.630 |