node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
daf-31 | hpo-29 | K07H8.3.1 | Y50D7A.4.1 | N-alpha-acetyltransferase daf-31; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). Plays a role in regulating larval development, metabolism and longevity. Functions downstream or alongside daf-3, daf-12 and daf-16 in the dauer formation pathway. Functions upstream of daf-15 to enable animal development. | Uncharacterized protein. | 0.999 |
daf-31 | rsd-2 | K07H8.3.1 | F52G2.2a.1 | N-alpha-acetyltransferase daf-31; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). Plays a role in regulating larval development, metabolism and longevity. Functions downstream or alongside daf-3, daf-12 and daf-16 in the dauer formation pathway. Functions upstream of daf-15 to enable animal development. | RSD-2 domain-containing protein. | 0.880 |
hpo-29 | daf-31 | Y50D7A.4.1 | K07H8.3.1 | Uncharacterized protein. | N-alpha-acetyltransferase daf-31; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). Plays a role in regulating larval development, metabolism and longevity. Functions downstream or alongside daf-3, daf-12 and daf-16 in the dauer formation pathway. Functions upstream of daf-15 to enable animal development. | 0.999 |
hpo-29 | rsd-2 | Y50D7A.4.1 | F52G2.2a.1 | Uncharacterized protein. | RSD-2 domain-containing protein. | 0.914 |
mut-16 | rde-10 | B0379.3a.1 | Y47G6A.4.1 | MUTator. | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | 0.569 |
mut-16 | rde-11 | B0379.3a.1 | B0564.11.1 | MUTator. | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | 0.694 |
mut-16 | rsd-2 | B0379.3a.1 | F52G2.2a.1 | MUTator. | RSD-2 domain-containing protein. | 0.736 |
mut-16 | rsd-6 | B0379.3a.1 | F16D3.2.1 | MUTator. | Tudor domain-containing protein. | 0.494 |
rde-10 | mut-16 | Y47G6A.4.1 | B0379.3a.1 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | MUTator. | 0.569 |
rde-10 | rde-11 | Y47G6A.4.1 | B0564.11.1 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | 0.973 |
rde-10 | rde-12 | Y47G6A.4.1 | F58G11.2a.1 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. | 0.851 |
rde-10 | rsd-2 | Y47G6A.4.1 | F52G2.2a.1 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | RSD-2 domain-containing protein. | 0.883 |
rde-10 | rsd-6 | Y47G6A.4.1 | F16D3.2.1 | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | Tudor domain-containing protein. | 0.705 |
rde-11 | mut-16 | B0564.11.1 | B0379.3a.1 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | MUTator. | 0.694 |
rde-11 | rde-10 | B0564.11.1 | Y47G6A.4.1 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | 0.973 |
rde-11 | rde-12 | B0564.11.1 | F58G11.2a.1 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. | 0.811 |
rde-11 | rsd-2 | B0564.11.1 | F52G2.2a.1 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | RSD-2 domain-containing protein. | 0.806 |
rde-11 | rsd-6 | B0564.11.1 | F16D3.2.1 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | Tudor domain-containing protein. | 0.705 |
rde-11 | sid-1 | B0564.11.1 | C04F5.1.2 | RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. | 0.672 |
rde-12 | rde-10 | F58G11.2a.1 | Y47G6A.4.1 | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. | RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets. | 0.851 |